I never thought about it before but I use upstream and downstream without much though. For my personal devices and containers I use Fedora but when it comes to servers and VMs I use Debian for its stable nature.
I also run Linux mint in my homelab with pcie pass though so it functions like a normal desktop.
Unless you want to run everything in the cloud you still need something bare metal. In my case I run Debian VMs on my proxmox cluster with docker and podman containers.