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Yes, that’s true. You lose reproducibility by using distrobox. But so far I did not need distrobox on my Guix laptop, the nonguix repo was enough. It was just a suggestion for somebody caring more about availability of packages than reproducibility to use Guix as the stable base and distrobox on top.
If you want to try OpenSUSE Tumbleweed without all these weird defaults: Try Gecko Linux.